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While typical therapeutic MPNs are employed, their rapid metal ion release, resulting from insufficient solution stability, impedes sustained efficacy during the various stages of wound healing. Robust (dually crosslinked), microenvironment-responsive, antibacterial, antioxidative, and anti-inflammatory copper-poly(tannic acid) nanoparticles (Cu-PTA NPs) are formulated to address these issues, hierarchically influencing the healing of infected wounds. Within the PTA scaffold, reactive polyphenols, covalently