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Overall, sNAMs proliferation could be steered to alter disease characteristics, including persistent neuropathic pain. Nucleophilic diarylzinc (ZnAr2) reagents, reacting with the Lewis acid Zn(C6F5)2, enable a mild and atom-efficient arylation of N-tosylimines, as we report here. The isolation of key intermediates within mechanistic studies reveals the cooperative activation of the imine substrate by the two zinc spec