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No statistically significant relationship was found between the parameters, clinical subtypes of onychomycosis and demographic characteristics (p.05). Patients with onychomycosis showed a shifted thiol/disulphide homeostasis towards oxidative stress with a reduction in thiols and an increase in disulphide/native thiol, and disulphide/total thiol ratios. These findings may indicate the role of oxidative stress in the pathogenesis of onychomycosis. Patients with onychomycosis showed a shifted thiol/disulphide homeostasis towards oxidati