https://www.selleckchem.com/pr....oducts/740-y-p-pdgfr
The therapeutic efficacy of the vaccine was associated with host skin-resident cells, the induction of a systemic, broadly reactive IFNγ CD8 T cell repertoire, increased frequencies of CD8 TIL and reduced levels of PD1 CD8 T cells. Extended survival was associated with improved TIL functionality, exemplified by the presence of enhanced levels of IFNγ CD8 TIL and IL2 CD4 TIL. These data support the use of a novel genetic vaccine for the effective treatment of localized or multifocal melanoma refractory to conventional αPD1-b
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