https://www.selleckchem.com/pr....oducts/ly3522348.htm
Systemic delivery of Ad5-3M to mice with localized or disseminated lung cancer led to viral ****tion in tumor cells, suppression of tumor growth, and prolonged survival. Thus, compound targeted mutagenesis of functional sites in the virus capsid represents a generalizable approach to tailor virus interactions with the humoral and cellular arms of the immune system, enabling generation of "designer" viruses with improved therapeutic properties.Endosomal trafficking has emerged as a defective biological pathway in Alzheimer's disease
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