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Hepatitis B surface antigen (HBsAg) seroclearance is considered a realistic goal in patients with chronic hepatitis B (CH, known as "functional cure". However, it remains elusive whether nucleos(t)ide analogue (NUC)-induced HBsAg seroclearance, compared with spontaneous HBsAg seroclearance, differs in its association with favorable long-term clinical outcomes. A total of 1,972 CHB patients with confirmed HBsAg seroclearance at least two consecutive times, 6months apart, were retrospectively analyzed. The risks of hepatocellular carcin