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Mast cells (MCs), playing a pivotal role in allergic conditions, necessitate the creation of therapies focused on their manipulation. The Ephedra herb, known as Mao, possesses potent anti-allergic properties, but the inherent presence of ephedrine alkaloids (EAs) mandates a cautious approach to its clinical application, considering its hazardous potential. In our earlier findings, Mao was shown to diminish the vigorous mast cell degranulation triggered by a