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Adolescents in the United States are at increased risk for acquiring HIV and other ****ually transmitted infections (STIs). Rates of chlamydia, gonorrhea, and primary and secondary syphilis are increasing among individuals aged 15 to 24 years, among both ****es. Approximately 1 in 5 new HIV diagnoses is occurring among individuals aged 13 to 24 years. Compared with hetero****ual and cisgender youth, ****ual and gender minority youth may be more likely to have had **** before age 13 years, and young transgender women have the highest rates of