https://www.selleckchem.com/pr....oducts/z-vad(oh)-fmk
Experimental autoimmune encephalomyelitis (EAE) is an animal disease model of multiple sclerosis (MS) that involves the immune system and central nervous system (CNS). However, it is unclear how genetic predispositions promote neuroinflammation in MS and EAE. Here, we investigated how partial loss-of-function of suppressor of MEK1 (SMEK1), a regulatory subunit of protein phosphatase 4, facilitates the onset of MS and EAE. C57BL/6 mice were immunized with myelin oligodendrocyte glycoprotein 35-55 (MOG ) to establish the EAE model.
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