https://www.selleckchem.com/pr....oducts/tlr2-in-c29.h
The rs74693964 C/T variant located 65 bp downstream of miR-145 genomic regions was observed to be associated with susceptibility to CRC (adjusted odds ratio (OR) 2.414, 95% CI 1.385-4.206). Cumulative effects of miR-143 and miR-145 on CRC risk were observed (Ptrend=0.03). Patients having CRC carrying variant genotype TT of KRAS rs712 had poorer survival (log-rank P=0.044, adjusted hazard ratio (HR) 4.328, 95% CI 1.236-15.147). Our results indicate that miRNA-related polymorphisms in miR-143/145 and KRAS are likely to be deleterious
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