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The results indicated that uvsE gene was successfully colonized and expressed and expression showed to be stable. Hek293T cells with recombinant uvsE gene showed efficacy at repairing 80% of CPD and 85% of 6-4 photoproducts during one hour, and more than 95% of damages over 4 h' repair time. Considering the outcome of this study, it could be concluded that the uvsE recombinant product is highly effective at repairing both CPD and 6-4 pp damages and could be considered as a preventive agent for UV-induced skin cancers. BACKGROUND Adverse ch
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