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Also, PTx inhibited TGF-β-induced Smad3 activation. Furthermore, PTx decreased cell migration and uPA expression stimulated by TGF-β. Remarkably, p38 MAPK mediated PTx inhibition of uPA activity induced by TGF-β but it was not implicated on cell migration inhibition. Conclusions PTx inhibits TGF-β induction of mouse Mφ migration and uPA expression, suggesting that PTx, as TGF-β targeting therapy, may enhance Mφ anticancer action within tumors.Purpose The main focus of the current research work was to unveil the anticancer activity of the