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The cholinergic system originating in the basal forebrain extends its projections throughout the neocortical mantle and to subcortical limbic structures, encompassing the hippocampus and amygdala. The cognitive deficits linked to various age-related neurodegenerative disorders, such as Alzheimer's disease, are theorized to stem from basal forebrain pathologies, particularly cholinergic dysfunction. A failure of normal afferent regulatio


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