https://www.selleckchem.com/MEK.html
This study investigated whether ivabradine, a selective If current inhibitor reducing heart rate (HR), is able to improve survival and prevent left ventricular (LV) remodeling in isoproterenol-induced heart damage. Wistar rats were treated for 6 weeks controls (n = 1, ivabradine (10 mg/kg/day orally; n = 1, isoproterenol (5 mg/kg/day intraperitoneally; n = 4, and isoproterenol plus ivabradine (n = 4. Isoproterenol increased mortality, induced hypertrophy of both ventricles and LV fibrotic rebuilding, and reduced systolic blood pressure (SBP)
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