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4% vs. 10%; odds ratio [OR]5.62), smoking history (30.7% vs. 12%; OR3.25), gastroesophageal reflux disease (26.9% vs. 8.0%;OR4.2) and non-adherence to medication (26.9% vs. 8.0%; OR4.2) were more likely to experience from exacerbation of asthma. It is important to identify risk factors that may cause acute exacerbation of asthma in the patients. Patients should be educated of the risk factors and complications of the exacerbation episode of asthma. It is important to identify risk factors that may cause acute exacerbation of asthma in the