https://www.selleckchem.com/pr....oducts/sar439859.htm
Furthermore, the aggravative effect of Snx8 deletion on NAFLD was validated in vivo, as hepatic steatosis and lipogenic pathways in the liver were significantly exacerbated in Snx8-knockout mice compared to wild-type controls. Consistently, hepatocyte-specific overexpression of Snx8 in vivo markedly suppressed HFHC-induced hepatic steatosis. Notably, the protective effect of SNX8 against NAFLD was largely dependent on FASN suppression. These data indicate that SNX8 is a key suppressor of NAFLD that promotes FASN proteasomal degradatio
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