https://cellcycleinhibitors.co....m/applying-the-the-y
The reported plasma clearance in healthy volunteers was roughly doubled when the measured clearance was 915,883 mL/min. In RH/HH cells, the intracellular accumulation of colistin exhibited a substantial rise when co-cultivated with the multidrug resistance-associated protein (MRP/Mrp) inhibitor benzbromarone. These findings point to the importance of hepatic metabolism in the non-renal clearance of colistin; conversely, t
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