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Nontuberculous mycobacteria (NTM) are ubiquitous environmental bacteria that may cause chronic lung disease and are one of the most difficult-to-treat infections among persons with cystic fibrosis (pwCF). Environmental factors likely contribute to increased NTM densities, with higher potential for exposure and infection. To identify water-quality constituents that influence odds of NTM infection among pwCF in Colorado. We conducted a population-based nested case-control study using patient data from the Colorado CF Center NTM database. W