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Time frames for all outcomes will start on the day of surgery. This manuscript serves as the formal statistical analysis plan (version 1. for the SCOPE randomized controlled trial. The statistical analysis plan was completed on 6 April 2021. ClinicalTrials.gov NCT03436290 . Registered on 16 February 2018. ClinicalTrials.gov NCT03436290 . Registered on 16 February 2018.Microbiology is at a turning point in its 120-year history. Widespread next-generation sequencing has revealed genetic complexity among bacteria t