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PTSD-PRSs predicted PTS and DS (R2 = 2.21% and 2.77%, padj less then 0.01), MDD-PRSs predicted DS and MSP (R2 = 1.89%, padj less then 0.01) and 0.79%, padj less then 0.05), and back pain-PRS predicted MSP (R2 = 1.49%, padj less then 0.01). Individuals in the highest quintile of PTSD-PRSs had 2.8 and 3.5 times the odds of developing PTS and DS vs. the lowest quintile (95% CI = 1.39-5.75 and 1.58-7.76). Among these high-risk individuals, those living in non-disadvantaged neighborhoods and with college education had 47% (p = 0.048)