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The MSPE-UHPLC-MS/MS method demonstrated its capability in real wastewater samples, and the complete analytical process, encompassing all steps from pretreatment to the quantitative results, took less than 30 minutes. In conclusion, a straightforward, rapid, precise, and trustworthy method for detecting trace amounts of psychoactive drugs in wastewater is the Fe3O4@PDA@poly(MAA-co-EGDMA) procedure. Due to their delicate and delightful flavor, melons (Cucumis