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In the PLS extracted from PDRG, there was a decrease in antioxidant load (p0.0001) coupled with an increase in pro-angiogenic molecules (p0.0001). This contrasted with an intravitreal increase (p0.0001) in pro-oxidants and a reduction (p0.0001) in antioxidants. In the PLS DMEG model, pro-inflammatory molecules and pro-oxidants were significantly increased (p 0.0001), while the antioxidant capacity was reduced (p 0.0001)