https://www.selleckchem.com/pr....oducts/thapsigargin.
We developed a method to simultaneously quantify airway narrowing and muscle shortening using 2-photon microscopy and demonstrated that inhibition of α2β1 mitigated IL-13-enhanced airway narrowing without altering muscle shortening by impairing the tethering of muscle to the surrounding matrix. Our data identified cell matrix tethering as an attractive therapeutic target to mitigate the severity of airway contraction in asthma.BACKGROUNDThe COVID-19 vaccines currently in use require 2 doses to achieve optimal protection. Currently,
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