1. Parasitic Worms (Onchocerciasis & Lymphatic Filariasis)

Ivermectin has long been the gold standard for treating parasitic worm infections like river blindness and elephantiasis. It’s recommended by the WHO and CDC for mass drug administration programs, particularly for onchocerciasis and strongyloidiasis mdpi.com+1es.wikipedia.org+1es.wikipedia.org+11en.wikipedia.org+11pmc.ncbi.nlm.nih.gov+11.

2. Rosacea and Demodex Mite Infestations

Topical ivermectin is FDA- and EU-approved for inflammatory lesions caused by rosacea and Demodex mite overgrowth. It has been safely used for over 25 years, providing solid evidence of its effectiveness and low risk of side effects jddonline.com.

3. Antiviral Potential (Including Emerging Viruses)

In laboratory and animal studies, ivermectin has shown promise against a range of viruses—such as Zika, dengue, yellow fever, West Nile, and even SARS-CoV-2—by inhibiting viral replication pathways nature.com. Notably, a Lancet study showed reduced viral loads in COVID-19 patients at high doses thelancet.com. However, larger human trials yielded mixed results, indicating the need for further research .

4. Anti-Inflammatory Effects (Rheumatoid Arthritis Model)

In a 2023 study on rats, ivermectin reduced inflammation in rheumatoid arthritis models, with effects comparable to dexamethasone. Results showed significant reduction in joint swelling and inflammatory markers researchgate.net.

5. Antibacterial and Antifungal Research

Research indicates ivermectin may possess broader antimicrobial activity. Though details are limited, early studies have suggested effects against certain bacteria and fungi, hinting at potential new therapeutic uses nature.com.

6. Anticancer Investigations

Lab studies indicate ivermectin can inhibit cancer cell growth across various cancer types, including colorectal cancer, by inducing apoptosis and blocking cell proliferation. It may also help combat chemotherapy resistance . Small clinical surveys reported self-medication in cancer patients, but medical professionals emphasize that conclusive human evidence is still pending .

7. Malaria Control

Though ivermectin isn’t a direct antimalarial, trials are exploring its effect on mosquito vectors and potential adjunctive therapy. Early results are promising, but clinical relevance remains uncertain .

8. Nonalcoholic Fatty Liver Disease (NAFLD)

A 2013 study identified ivermectin as a ligand for the FXR receptor, which plays a role in liver health. This has sparked interest in its possible role for treating metabolic conditions en.wikipedia.org.

9. Neurological and Neuroprotective Uses

Research into ivermectin’s action on neurological channels and its safety at higher doses suggests untapped potential for neurological diseases—but this is still in early experimental stages .

10. Complex Infectious Syndromes (e.g., Strongyloides Co-Infection with COVID-19)

Ivermectin is recommended for treating Strongyloides infections, especially in patients who receive steroids for COVID-19, to prevent dangerous hyperinfection syndromes. Agencies like WHO and PHAC advise this co-treatment en.wikipedia.org.

⚠️ Important Considerations

• Lab findings don’t always translate to human benefit. Most uses beyond parasitic infections are still exploratory or based on small trials.

• Dosage and safety matter. Ivermectin is generally well tolerated at approved doses, with mostly mild side effects .

• Regulatory status varies. Only parasitic parasites and rosacea are currently approved uses. Others fall under “investigational” or “off-label.”

Conclusion

Ivermectin is much more than a dewormer—its anti-inflammatory, antiviral, anticancer, and metabolic effects make it a compelling candidate for deeper research. For now, only use it for approved conditions and under medical supervision.