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Cerebrovascular comorbidity increased the risk of disease severity (odd ratio = 4.4; 95% CI 1.48 to 12.84) and mortality (odd ratio = 7.0; 95% CI 2.56 to 18.99). Statistical analyses showed that CRP and D-dimer serum levels were elevated by six-folds in the severe cases of COVID-19 patients. This significant increase in these two proteins levels can serve as a vital indicator for COVID-19 patients who are at increased risk of severe COVID-19 cerebrovascular complications, such as stroke. To propose a diagnostic algorithm for improving the