https://www.selleckchem.com/products/rp-6306.html
© 2020 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim.BACKGROUND Activated protein C (APC) downregulates thrombin generation by inactivating procoagulant cofactors Va and VIIIa by limited proteolysis. We identified two protein C-deficient patients both of whom carry a heterozygous Gly197 to Arg (G197R) mutation in PROC and experience venous thrombosis. OBJECTIVE The objective of this study was to determine the molecular basis of the clotting defect in patients carrying the G197R mutation. METHODS We expressed protein C-G197R in mammalia
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