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The ZnO catalytic activity will be beneficial toward generating stable NO release for long-term biomedical applications. © 2020 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim.We develop a novel smartphone-based spectral imaging otoscope for telemedicine and examine its capability for the mobile diagnosis of middle ear diseases. The device was applied to perform spectral imaging and analysis of an ear-mimicking phantom and a normal and abnormal tympanic membrane for evaluation of its potential for the mobile diagnosis. Spectral classifie