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For all the study period, the PCV was 17% and the PPV was 35%. Influenza vaccination in mothers during pregnancy prevented influenza confirmed hospitalizations in infants aged 6months and younger with a 61% (95%CI 27-79%) effectiveness. In line with evidence from other countries, influenza vaccination during pregnancy protects infants up to 6months of age from influenza hospitalizations in Spain. These results support current recommendations of influenza vaccination in pregnant women, and more studies are needed in Spain to confirm the