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High-fat diet-related depressive symptoms might experience their lipid homeostasis imbalances modulated by KP. KP's ameliorative effect on cholesterol metabolism dysfunction was validated, which corresponded with increased activity in the AdipoR1-BDNF (brain-derived neurotrophic factor) co-regulatory pathway. Our results demonstrate KP's capacity to alleviate depression, potentially through a multi-target approach that includes modulation of cholesterol metabolism and adi