https://www.selleckchem.com/pr....oducts/incb059872-di
ATR is a master regulator of cell response to ****tion stress. Adequate activation of ATR is essential for preventing genome aberrance induced by ****tion defect. However, the mechanism underlying ATR activation is not fully understood. Here, we identify that RBMX is an ssDNA binding protein that orchestrates a novel pathway to activate ATR. Using super-resolution STORM, we observe that RBMX and RPA bind to adjacent but nonoverlapping sites on ssDNA in response to ****tion stress. RBMX then binds to and facil
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