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essfully recaptured with tofacitinib 10mg b.d. retreatment in a substantial proportion of patients. ClinicalTrials.govNCT01458574;NCT01470612. Higher levels of insulin-like growth factor-1 (IGF-1) are associated with increased risk of cancers and higher mortality. Therapies that reduce IGF-1 have considerable appeal as means to prevent recurrence. Randomized, 3-parallel-arm controlled clinical trial. Cancer survivors with overweight or obesity were randomized to 1) self-directed weight loss (comparison), 2) coach-directed weight loss, or