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Five-fold higher concentrations were needed to damage neuronal cells in vitro. In conclusion, penetration of the intact blood-brain barrier by bortezomib is low. Overall, our data show that bortezomib is a safe medication in terms of central nervous system toxicity.This scientific commentary refers to 'Analysis of α-synuclein species enriched from cerebral cortex of humans with sporadic dementia with Lewy bodies', by Sanderson et al. (https//doi.org/10.1093/braincomms/fcaa01.Charcot-Marie-Tooth disease type 1A, caused by a duplication o
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