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Yet, the question of whether unique metabolic features of pluripotent stem cells (PSCs) are linked to the function of the biological clock remains unanswered. In exploring the transition of somatic cells to a pluripotent state, we highlighted unique non-canonical functions of the circadian repressor CRY1, specific to PSCs. The presence of CRY1 in PSCs was directly tied to metabolic reprogramming, involving the inactivation o
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