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In this review, we compare and contrast the most frequent mechanisms of antiandrogen and antiestrogen resistance, and provide potential therapeutic strategies for targeting both advanced PCa and BCa.Brown adipose tissue (BAT) is a metabolically active organ that exhibits ****-differential features, that is, being generally more abundant and active in females than in males. Although **** steroids, particularly estrogens, have been shown to regulate BAT thermogenic function, the underlying molecular mechanisms contributing to ****ual dimorphis