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Background The use of platelet-rich plasma (PRP) in the Medicare population is not well described. Purpose To investigate the national use of PRP among Medicare beneficiaries, including the incidence and conditions for which it was used in both operative and nonoperative settings, and determine charges to Medicare. Study Design Descriptive epidemiology study. Methods The Medicare Standard Analytical Files within the PearlDiver database were queried for PRP injections by use of Current Procedural Terminology (CPT) code 0232T from 2010 to