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The 1-year and 3-year DFS rates were 75.00% and 70.83% in group A1, 70.59% and 58.82% in group A2, 46.67% and 40.00% in group A3, with significant difference(P less then 0.05). The 1-year and 3-year OS rates were 83.33% and 75.00% in group A1, 73.53% and 50.00% in group A2, 46.67% and 40.00% in group A3 , with significant difference(P less then 0.05). In group A3, there were 4 cases (13.33%) of low-risk TP53 mutation (LR), 12 cases (40.00%) of high-risk TP53 mutation (HR), 4 cases(13.33%) of wild-type TP53 mutation (Wt), and 10 cases(3