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While we found no evidence for total cerebellar volume alterations with increased polygenic scores for any thyroid trait, opposing influences of increased polygenic scores for hypo- and hyperthyroidism were found in the pallidum (PT 1e-3 β [95% CI] = -0.02 [-0.03, -0.01], P = 0.0003 and PT 1e-7 β [95% CI] = 0.02 [0.01, 0.03], P = 0.0003, respectively). Neither hypo- nor hyperthyroidism showed evidence of regional genetic pleiotropy with ADHD. Thyroid status affects gray matter volume in adults, particularly at the level of the