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Here, I will review recent developments in our understanding of ligand recognition and binding promiscuity within the SLC15 family, and discuss current models for prodrug recognition. © 2020 The Author(s).Little is known about the functional relationship of delaying second-line treatment initiation for HIV-positive patients and mortality, given a patient's immune status. We included 7255 patients starting antiretroviral therapy between 2004-2017, from 9 South African cohorts, with virological failure and complete baseline