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77 days (weighted mean difference=-4.77; 95% CI -6.45 to -3.09; p less then 0.001) and significantly increased the wound healing rate on days 7, 10, 14 and 20 by 6.46%, 19.78%, 17.07% and 11.38%, respectively. There was no significant difference between the groups in the wound healing rate on day 28 and average optical densities of VEGF and FGF. No systematic adverse event occurred. Redder, more swollen and painful wounds were reported after using rhGM-CSF compared with the control. CONCLUSIONS rhGM-CSF could be effective and safe for tr