https://www.selleckchem.com/pr....oducts/imidazole-ket
In line with experiments, the reactivity of isocyanates toward nucleobases decreases in the order cytosine adenine guanine, and we rationalize this order of reactivity by the fall of their basicity and destabilization of the imine forms. Activation barriers of the alternative concerted pathways are higher than that of the preferred stepwise mechanism, and the match to experiment is poor. The kinetic effect of adding electron-withdrawing or electron-donating groups to the aryl group of aryl isocyanate is minute
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