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6% vs. 66.9%, p = 0.01). After age-adjustment, CCS had worse OS (Hazard ratio CRC = 2.449, p 0.01, melanoma = 6.503, p 0.01, BC = 3.383, p 0.01). CCS were younger when diagnosed with a SM. After age-adjustment, OS was diminished. Heightened surveillance may be necessary for CCS diagnosed with SM. CCS were younger when diagnosed with a SM. After age-adjustment, OS was diminished. Heightened surveillance may be necessary for CCS diagnosed with SM. The goal of this study was to comprehensively investigate the association of che