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Efficient charge separation and utilization are critical factors in photocatalysis. Herein, it is demonstrated that the complete spatial separation of oxidation and reduction cocatalysts enhances the efficacy of charge separation and surface reaction. Specifically, a Pt@NH2 -UiO-66@MnOx (PUM) heterostructured photocatalyst with Pt and MnOx as cocatalysts is designed for the optimization of the NH2 -UiO-66 photocatalyst. Compared with the pristine NH2 -UiO-66, Pt@NH2 -UiO-66 (PU), and NH2 -UiO-66@MnOx (UM) samples, the PUM sample exhibit