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Quantitatively assess the inhibitory effect of dextran-coated -Fe2O3 ultrasmall superparamagnetic iron oxide nanoparticles (dUSPIONs) on human DNA repair proteins APE1 and MTH1. Isotope-dilution liquid chromatography-tandem mass spectrometry served to determine the expression levels of APE1 and MTH1 in MCL-5 cellular populations following exposure to growing doses of dUSPIONs. Analysis