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A detailed examination of the immunoregulatory function was conducted in cyclophosphamide-induced immunosuppression mouse models, and in murine splenocytes and macrophages. PNPB1, a novel homogeneous polysaccharide isolated from notoginseng, had a molecular weight of 93,105 Daltons. From monosaccharide composition analysis of PNPB1, the constituent components were identified as