https://www.selleckchem.com/pr....oducts/5-cholesten-3
A convenient additive-free synthesis of dihydro-4H-1,2-oxazines via a Cloke-Wilson type ring expansion of the aryl substituted cyclopropane carbaldehydes (ACC) with the hydroxylamine salt is introduced. Comparatively less active cyclopropyl ketones also follow a similar protocol if supplemented by catalytic pTSA.H2O. The transformation is performed in an open-to-air flask as it shows negligible sensitivity towards air/moisture. Dihydro-4H-1,2-oxazines when subjected to cycloaddition with the cyclopropane diester, affo
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