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Thus, we suggest that targeting vascular apelin may serve as an alternative strategy for anti-angiogenesis in GBM.As the main place of people's daily activities, indoor space (its size, shape, colors, material and textures, and so on) has important physical, emotional and health-based implications on people's behavior and quality of life. Material texture is an integral part of architectural environment perception and quality evaluation, but the effect of material texture on perceptual spaciousness lacks the support of experimental data. T