https://cdantigens.com/index.p....hp/immuno-oncology-p
Telmisartan's influence on morphine analgesic tolerance in rats was further investigated using the tail-flick method. To assess morphine potency and efficacy, a [35S]GTPS-binding assay was performed on spinal cord samples from treated neuropathic animals. Finally, the measurement of glutamate within the cerebrospinal fluid (CSF) was accomplished by means of capillary electrophoresis. An acute antiallodynic effect was observed with higher doses of oral telmisartan or losartan. Subanalgesic doses of telmisa