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This study shows that ocean acidification has no significant effect on P. damicornis microbiome, and warrants further research to test whether transgenerational acclimation exists in coral holobiont to projected future climate change.Resting-state functional connectivity (RSFC) has widely been used to examine reorganization of functional brain networks during normal aging. The extraction of generalizable age trends, however, is hampered by differences in methodological approaches, study designs and sample characteristics. Distinct age r