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Regarding BDNF protein levels, the ACE-exposed and unexposed groups exhibited no appreciable divergence (ROM 108; 95% CI 093-126). Variations in age at sample collection, analyte type (such as serum, plasma, or whole blood), and ACE exposure categories significantly contributed to the high degree of heterogeneity across studies; however, this was partly mitigated through subset-specific analyses. These results strongl