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The possibility to achieve charge-to-spin conversion via Rashba spin-orbit effects provides stimulating opportunities toward the development of nanoscale spintronics. Here, we use first-principles calculations to study the electronic and spintronic properties of Tl2O/PtS2 heterostructure, for which we have confirmed the dynamical stability by its positive phonon frequencies. An unexpectedly high binding energy of -0.38 eV per unit cell depicts strong interlayer interactions between Tl2O and PtS2. Interestingly, we disc